Wildfire smoke may help virus spread, mouthwash helps curb it

VirologyCoronavirusTranslational Medicine Stem CellsNews      SARS-CoV-2 Infection Modeled in 3-D Stem Cell Culture Model

"Our immune system recognizes the virus SARS-CoV-2 as harmful and produces antibodies in response to it, which helps to fight the virus", said study author Marc Veldhoen from Medicina Molecular Joao Lobo Antunes in Portugal. Now a study by Portuguese researchers has found that the majority of patients have detectable antibodies against COVID-19 for up to seven months after the contraction of the infection.

A new study from Penn State College of Medicine suggests that the human coronavirus may be "inactivated" by use of oral antiseptics and mouthwash.

Neuropilin-1 is thought to accelerate the speed of transmission of Sars-CoV-2, the virus that causes COVID-19, between people, The Independent reported.

To examine this, a team from Penn State University exposed human liver cells in culture with mixed solutions containing HCoV‐229e and either mouthwash, a nasal rinse product, or baby shampoo diluted to 1 percent.

Meyers said the next step is to expand upon these results by conducting clinical trials that can evaluate whether these over-the-counter products can effectively reduce viral loads in coronavirus-positive patients. In other words, we haven't yet tested in people the effects of using products like mouthwash on coronaviruses.

Meyers led a team of physicians and scientists who replicated the interaction of the virus in the nasal and oral cavities with rinses and mouthwashes.

Mouthwashes, oral rinses may inactivate human coronaviruses. Importantly, by using monoclonal antibodies - lab-created proteins that resemble naturally occurring antibodies - or a selective drug that blocks the interaction we have been able to reduce SARS-CoV-2's ability to infect human cells.

The solutions interacted with the virus for 30 seconds, 1 minute, and 2 minutes, before diluting the solutions to prevent further inactivation.

The team infected the organoids with a strain of SARS-CoV-2 taken from a patient in South Korea who had been diagnosed with the COVID-19 virus. After counting how many cells remained alive after a few days of exposure to the viral solution, this number was used to calculate the amount of human coronavirus that was inactivated as a result of exposure to the mouthwash or oral rinse that was tested.

Mouthwashes with antiviral ingredients could help decrease COVID-19 transmission by reducing viral loads in the mouths of infected patients when they cough, sneeze or speak, according to a paper in the Journal of Dental Research published on Thursday.

The 1% baby shampoo solution, which is often used by head and neck doctors to rinse the sinuses, inactivated greater than 99.9% of human coronavirus after a two-minute contact time.

"Based on our model we can tackle many unanswered key questions, such as understanding genetic susceptibility to SARS-CoV-2, assessing relative infectivity of viral mutants, and revealing the damage processes of the virus in human alveolar cells", said Young Seok Ju, MD, PhD, co-senior author, and an associate professor at Korea Advanced Institute of Science and Technology.



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