Urgent vaccination proves inactivated COVID-19 vaccines effective

Pascal Soriot chief executive of the drug company AstraZeneca in Washington on Feb. 26 2019. Researchers say drug companies need to be more open about how vaccine trials are run to reassure Americans who are skittish about getting a coronavirus vaccine

After days of uncertainty following a safety alert in the global trials for one of the frontrunners in the Covid-19 vaccine race, AstraZeneca on Saturday said it is resuming human testing in the United Kingdom of the vaccine candidate it developed jointly with Oxford University.

"On 6 September, the standard review process triggered a voluntary pause to vaccination across all global trials to allow review of safety data by independent committees and worldwide regulators".

"The UK committee has concluded its investigations and recommended to the MHRA that trials in the UK are safe to resume", it added. Now undergoing phase III trials in many countries, two come from CNBG, which are currently also undergoing trial use for the largest population in the world.

The pharma giant also stated that it had "voluntarily paused" the trial. The company hopes that a vaccine would be ready by year-end or early 2021. Trials could restart depending on the outcome of an independent review of the potential safety concern.

AstraZeneca announced on Wednesday it had "voluntarily paused" its trial of the vaccine developed alongside Oxford University after the volunteer developed an unexplained illness. Overseas trials have been expanded in regard to ethnicity, countries, and larger populations, and most importantly, they have been recognized by global community, which is very good for future applications, he said.

"Instinctively I feel a little more comfortable with inactivated vaccines because we have a lot of experience with them", he said.


The human trials resumed days after a pause had been announced in the trials after an adverse reaction in one of the participants.

A Chinese pharmaceutical company has injected hundreds of thousands of people with experimental Covid-19 vaccines, as its Western counterparts warn against administering mass vaccinations before rigorous scientific studies are complete.

Meanwhile, in an order on Friday, the drug controller general of India VG Somani directed the Pune based vaccine maker to suspend recruitments till further orders.

Charlotte Summers, lecturer in intensive care medicine at Cambridge University, said the pause showed the researchers' commitment "to putting safety at the heart of their development programme".

Serum Institute has a production and distribution alliance on this vaccine candidate in low- and middle-income countries.

Odoemena said Russia's action also poses a potential health risk, adding that already following Russia's "misstep" is China, which has made a decision to approve Sinovac's COVID-19 vaccine candidate. Logunov explained that the 42nd day after vaccination is considered the peak of the immune response as all the volunteers who participated in the drug trials developed antibodies by that time.

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