She said Mr Depp did not expect his wife to continue working with "young and attractive actors".
Actor Johnny Depp, 57, took The Sun's publisher News Group Newspapers (NGN) to court over a 2018 article which labelled him a "wife beater". He strongly denies being violent to Heard.
Judge Andrew Nicol is expected to take some days poring over 12 volumes of evidence submitted in a case that was born at the height of the #MeToo movement.
Johnny Depp gestures as he leaves after the end of the trial at the High Court in London. The outcome of the case is likely to have an impact on another case in the US, where Depp has sued Heard for $50 million over a piece she wrote in The Washington Post, where she talks about herself as a domestic abuse survivor. It's all about proving he's not a wife beater.
Amber Heard, with lawyer Jennifer Robinson (right) and partner Bianca Butti (left) gives a statement outside the High Court in London.
The former couple have been back and forth in court in the past month.
Lawyers, journalists and members of the public, spread across several video-linked courtrooms to allow for physical distancing, have heard lurid details of the couple's tempestuous relationship.
The barrister added: "I'm sorry - there are many, many victims of domestic violence and different situations, but this is a huge disservice to those genuine victims, as well as the MeToo movement, for Ms Heard to count herself as one of them, as she plainly does".
But summarising for the defence, lawyer Sasha Wass said Depp was often "so severely impaired by drug use" that he may not have been aware of the extent of his "violence and terrifying behaviour".
Sherborne accused Heard of repeatedly changing her story as the case went on.
Depp's lawyers insisted that this incident was a "one-off" and that "no other human being is supposed to have witnessed Depp being violent towards Heard".
Wass said that for Depp the "combination ... of drink, drugs, jealousy and anger was lethal".
Some legal experts say Depp's reputation will have trouble recovering, even if The Sun is forced to retract its claim. While his drug use was acknowledged, the overarching narrative denied any signs of abuse.
Earlier, Sherborne had referred to evidence given by Heard that Depp had thrown his former girlfriend Kate Moss down the stairs.
Wass said those witnesses were "tainted" because they relied on Depp for their livelihoods and had "come to court to lie for their boss".
Prior to the hearing, Depp arrived at the court to a warn reception from his largely female fans.
"Can you imagine what consternation there would be?"
"Mr Depp has spent his entire adult life doing exactly what he wanted, and he was not about to answer to a woman at this stage in his life", she said.
In his testimony, Depp said he modelled himself as a "Southern gentleman" who would never strike a woman.
The soiled sheets were discovered by a cleaner who was convinced the mess was made by a human and not from their pet Yorkshire terriers.Ms Heard's defence said the faeces were from one of their pet dogs Boo who "had problems with her toilet habits".The court also heard that their dog had toilet trouble after eating a bag of Depp's marijuana."Amber Turd", "MePoo" and "PoopGate" all trended on Twitter shortly after the incident was revealed during the trial but United States media have politely called it "the poop incident".
Kodak shares up after COVID-19 drugs deal
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