They hope the low-priced treatment can keep patients off ventilators.
Aside from ibuprofen, another medicine that was believed to ease the pain for coronavirus patients is paracetamol.
Researchers in the United Kingdom are working to determine if ibuprofen, an everyday anti-inflammatory painkiller, can treat breathing difficulties in COVID-19 patients.
The trial, called Liberate, involves the randomized distribution of ibuprofen to half of the patients in the study in addition to providing them with the usual COVID-19 care.
"Theoretically, this treatment, given at this time, should be beneficial".
Professor Matthew Hotopf, one of the team from Kings College London and one of the lead researchers, said: "This highly innovative therapeutic approach seeks to rapidly advance a potentially important new treatment".
Note that previously studies on animals have shown that ibuprofen might treat acute respiratory distress syndrome, which is one of the major complications caused by severe coronavirus infections.
But when they are given this special formulation of ibuprofen the survival rates increase to 80%.
The Liberate trial is a joint effort between experts from Guy's and St Thomas' NHS Foundation Trust, King's College London and the pharmaceutical organisation the SEEK Group.
The trial will use a liquid capsule form of ibuprofen rather than the tablets that people can get for themselves in local pharmacies and supermarkets.
It is hoped that the way the drug has been formulated will reduce potential gastric side effects linked to ibuprofen.
"As a new illness, there are limited treatment options for patients with COVID-19", said Richard Beale, a professor of intensive care medicine.
"If successful, the global public health value of this trial result would be vast given the low cost and availability of this medicine", said Matthew Hotopf, director of NIHR Maudsley Biomedical Research Centre.
At the onset of the global COVID-19 pandemic, taking ibuprofen was considered a risk for virus carriers even with mild symptoms.
Now, some scientists think that ibuprofen may, in fact, be an effective defense against COVID-19, according to the US National Library of Medicine's clinical trials database.
Later the French health minister Olivier Véran bolstered the claim when he said the drug could "aggravate the infection".
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