"By fair we mean that in the study of the [COVID-19] origin, political interference should be avoided", Wang Yi said.
United States President Donald Trump threatened last week to pull funding from the World Health Organization, calling it an organisation that only serves China, allegations Beijing has furiously refuted.
The introduction in China's legislature on Friday of a proposal to impose a security law in Hong Kong to suppress the semi-autonomous city's pro-democracy movement has further raised the temperature, drawing USA and world condemnation.
The Chinese diplomat, however, expressed his deep sympathies to the USA for the pandemic.
"Aside from the devastation caused by the novel coronavirus, there is also a political virus spreading through the US", Wang said during a press conference on the side of the annual legislative meeting.
"Some politicians completely disregard basic facts and have fabricated too many lies targeting China, and plotted too many conspiracies".
The Global Times, a newspaper affiliated with the Communist Party, reported Sunday that China was "considering punitive countermeasures" against some American politicians leading the efforts to hold it accountable for the virus. "We will work with more countries to establish joint prevention and control mechanisms, contribute to global cooperation in combating the epidemic and to the construction of a Health Silk Road", he said.
"I want to say here: Don't waste precious time any longer, and don't ignore lives", he said.
"What China and the United States need to do the most is to first learn from each other and share their experience in fighting against the epidemic".
This includes, most recently, a claim by White House trade adviser Peter Navarro that China "sent hundreds of thousands" of people infected with the virus on planes to "seed" the virus around the world.
China is also open to working with the worldwide community to look into the origins of the virus, said Mr Wang, who was speaking on the sidelines of China's annual parliament sessions.
Yi who is China's foreign minister said the USA is not only battling the coronavirus but also "a political virus".
Wang also offered his strong support for the World Health Organization (WHO) and its chief, Tedros Adhanom Ghebreyesus, frequent targets of U.S. criticism.
People in Australia must stay at least 1.5 metres away from others.
New Zealand PM unruffled as quake hits mid-interview
The natural disaster also interrupted Prime Minister Jacinda Ardern mid-interview, which was caught on camera. The quake was 46 kilometres deep and 25km northwest of Levin, according to government seismic monitor Geonet.