He tweeted: "Over here on E Street, we are crushed by the loss of John Prine".
The New York Times, the Tennessean and Rolling Stonereported that Prine's family confirmed his death from COVID-19.
John Prine, an American folk legend widely considered one of his generation's most influential songwriters, died following complications of coronavirus Tuesday, his publicist told AFP on behalf of his family.
Prine was hospitalised on March 26 suffering from symptoms of Covid-19, the respiratory disease caused by the novel coronavirus, according to his wife, Fiona Whelan Prine, who was also his manager.
One singer-songwriter was able to see a ray of hope in the outpouring: "You know what does my heart good on a blue blue day?" wrote Matraca Berg. "Thank you for every single time I got to stand beside you and sing those once in a lifetime songs". After returning from West Germany where he served in the U.S. military, Prine moved to Chicago and began writing songs.
Born October 10, 1946 in Maywood, Illinois, Prine took up music as a hobby before emerging on the Chicago folk revivalist scene in the late 1960s, when he was discovered by country star Kris Kristofferson.
In the 1980s, fed up with the recording industry, he started his own label, Oh Boy Records, releasing albums under that imprint for the next several decades. He won the Grammy for Best Contemporary Folk Album in 1992 and 2006 for The Missing Years and Fair & Square, respectively.
Prine's songwriting has been honored by the Americana Music Awards, the Nashville Songwriters Hall of Fame, and more institutions. Most recently, he was diagnosed with lung cancer in 2013 and had part of a lung removed. In 1998 he received a squamous cell cancer diagnosis and had surgery to remove diseased tissue in his neck, severing several nerves.
"If I can make myself laugh about something I should be crying about, that's pretty good", he once said.