They told TMZ at the time that they chose to remove the respirator and stopped giving her medicine once it became apparent that she would not be able to recover.
Nickerson was a child actress when she played Violet Beauregarde, the girl who blows up into a large blueberry shape after breaking factory rules, in the 1971 musical film with Gene Wilder.
Denise sadly suffered a severe stroke in June of 2018.
They posted Wednesday morning that she was taken off life support.
When they came back home and realized what happened they rushed her to the ER where her condition worsened. "None of it was helping, but making her only more uncomfortable", he wrote.
The family reported that Nickerson suffered a "severe stroke that caused extreme damage" a year ago and was taken to the emergency room and ICU on Monday, suffering pneumonia.
Denise's son, Josh, previously said it was "a matter of time" before her death.
"They just took off all the equipment". He explained that although Denise achieved fame and success as an actress early in life "she has no inheritance".
Bad turn: The 62-year-old actress' family has chose to end any more medical help after she was rushed to the hospital this week.
The family is using their Go Fund Me page to fulfill Nickerson's final wish to be cremated and have her ashes made into a piece of glass art. We will need to urgently pay for these things as well as need help with our home expenses. "We need help. Anything you can spare is a big help".
Her only child started a fundraising page to raise money for the actress' funeral costs after she was placed on life support. "Even if you can't donate simply sharing the link, and sharing our story so we can send Denise off and get some help and peace over the next few months would be so incredible".
Born on April 1, 1957, in New York City, before starring in one of the most iconic films of the century, Nickerson's first acting job was playing Amy Jennings/Nora Collins/Amy Collins on the TV series Dark Shadows.