Sources close to the family says that he died from a possible heart attack.
Marshall had a strained relationship with his son and the pair had been estranged for years.
Mathers Jr. married Eminem's mother Debbie when he was 22 and she was 15. They split up shortly after, and Eminem and his mom moved to Detroit with her family while Bruce moved to California where he had two other kids.
He also starred in his film 8 Mile in 2002 where he won an Academy Award for Best Original Song Lose Yourself.
Bruce struggled with his demons, eventually attending Alcoholics Anonymous and counselling sessions at a rehab centre. In his smash hit 'My Name Is, ' for which he won a Grammy in 2001, Eminem rapped about a dream where he cut his father's throat.
In the latter track he rages: "My f.t father must've had his panties up in a bunch "Cause he split, I wonder if he even kissed me goodbye".
"No, I don't, on second thought, I just f**kin' wished he would die".
Eminem's biological father has died.
In the letter, he wrote: "I desperately want to meet him and tell him I love him". I work hard, I have money.
"I don't know anything about my dad and I don't care", the paper reported the singer as saying.
Eminem hasn't publicly acknowledged his father's death.
When addressing his situation with his father, he told the publication: "They'd tell me he was a good guy: 'We don't know what your mother's told you, but he was a good guy'". Eminem, meanwhile, told the magazine that he heard his dad had been "trying to get in touch" with him once he became famous. I never got one letter. "He could have done something - made an effort".
Bomb threat to Air India flight to United States was a hoax
The RAF jets caused a sonic boom over Derby, with concerned residents taking to social media to share their experiences. Air India tweeted that the plane made a "precautionary landing" because of a bomb threat, but later deleted the post.