As a Rock N Roll Hall of Fame inductee, six time Grammy victor, songwriter, composer, producer, and performer, he created a unique blend of music which carried his home town, New Orleans, at its' heart, as it was always in his heart.
Dr. John scored his six Grammy Awards for "Makin' Whoopee" in 1989; his album Goin' Back to New Orleans in 1992; Best Rock Instrumental Performance for SRV in 1996; "Is You Is, or Is You Ain't (My Baby) in 2000; the album City That Care Forgot in 2008; and album Locked Down in 2012".
Memorial arrangements were being planned.
Dr. John is known for blending psychedelic rock with traditional New Orleans folk music.
It added: "The family thanks all whom shared his unique musical journey & requests privacy at this time".
Dr John was inducted into the Rock and Roll Hall of Fame by fellow singer-songwriter John Legend in 2011.
A white man who found a home among black New Orleans musicians, he first entered the music scene when he accompanied his father, who ran a record shop and also fixed the P.A. systems at New Orleans bars.
Dr. John was a major feature at worldwide jazz festivals and was known for mingling English with French Creole and African patois in a cultural mix specific to New Orleans and its multicultural history.
Debbie Harry, the lead singer of Blondie, shared a picture of the two together and wrote: "RIP Mac Rebennack, Dr John".
He gained recognition with his solo hit Right Place, Wrong Time.
Music critic Ted Gioia also reflected on his loss.
"New Orleans, we gave the world a lot of things: the music, the food, a lot of things!" "He showed the world Louisiana's rich musical heritage, and his passion for music has left a mark on the industry unlike any other".
"I don't feel like I can trust anybody, anywhere." he said.
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