The West Indies, who unlike Ireland have qualified for the upcoming World Cup in England and Wales, were behind the run-rate at 112 for two in the 20th over.
But a third-wicket stand of 128 between Ambris, playing only his fourth ODI, and Roston Chase (46) helped get the tourists back on track.
Opting to bat first, Ireland score a competitive 327-5 with Paul Stirling 77, Andrew Balbirnie 135 and Kevin O'Brien 63 the mainstays of their batting and Shannon Gabriel 2-47, the pick of the bowlers for the Windies. Jason Holder, who bowled the 48th over was clubbed for three consecutive sixes before holing out off a bouncer. However, with Stirling on 77, he hooked a Shannon Gabriel bouncer straight into the hands of fine leg. William Porterfield fell soon after for 3, however, Kevin O'Brien proved to be the flawless foil for Balbirnie, who continued to push along at a run a ball before completing his hundred off his hundredth ball. The batsman recorded his career-best score of 170 runs in the opening match against Ireland and along with fellow opener John Campbell, he registered the highest ever ODI opening partnership of 365 runs.
Darren Bravo only made 17 runs before he was dismissed by Stirling.
"It wasn't best day in the office", Irelandall-rounder Kevin O'Brien said after his side failed to catch the Windies' 381, according to RTE. While Balbirnie smashed 11 sixes and four fours, O'Brien managed three fours and as many maximums.
The West Indies pounded Ireland for a 196-run victory in the Tri-Nation Series opener.
Carter and Holder took the initiative after Ambris fell, ensuring West Indies successfully chased a total of over 300 for just the second time in their ODI history. However, West Indies' firepower in batting meant they had enough in the tank to chase the target down on a flat pitch, even if the outfield was rendered sluggish due to rain on the previous day.
A classy 135 from Andy Balbirnie gave Ireland hope of a first win in the Tri-Nations series but they slumped to a second loss to the Windies in a week. Shai Hope, who is has been in terrific form in this series and Sunil Ambris played with great fluency from an early stage and put Ireland on the back foot. He put on a brisk 146 with Stirling for the second wicket, with the opener mixing caution with bursts of explosion in contrast to Balbirnie's more even-tempered knock.
West Indies dominated their first meeting with Ireland entirely. Having lost two of their three matches so far, with one game abandoned, Ireland are out of contention to qualify for the final.
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