Officials blamed four deaths last week on the flooding, which forced hundreds of people in Iowa, Illinois and Missouri from their homes.
The Mississippi and Missouri rivers and their tributaries are already flooding, causing levee breaches and evacuations.
The river - a key transportation artery for shipments of grain, agricultural chemicals, energy products, and other commodities - is closed from river mile marker 179 to 184, the Coast Guard said.
Fuchs says he is especially concerned about the potential for a new rise in the Missouri River, including in areas of Nebraska, Iowa, Kansas and northwestern Missouri that were flooded in late March.
The Mississippi River has crested at numerous hardest-hit towns, but with more heavy rain expected over the next several days, the latest round of spring flooding may be far from finished.
During the historic flooding in July 1993, the Mississippi River near Davenport rose to its highest level ever: 22.63 feet.
The bulging MS tore through a levee in St. Charles County, near St. Louis, forcing evacuations.
The river is expected to crest early Monday morning at almost 12 feet above flood stage which could put it into the top five of all time. Parkland and some roads are flooding. The high water also has closed regional locks and dams to navigation. Much of eastern Kansas and western Missouri were under flood warnings.
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