Meanwhile, Zidane's reversion to familiar faces also saw Keylor Navas get the nod in goal ahead of summer recruit Thibaut Courtois, and having missed the win over Valladolid due to injury, Gareth Bale returned after a week where his future at the club was thrown into the spotlight once more.
The Frenchman led Madrid to three consecutive Champions League titles before surprising the football world by handing in his resignation.
Zidane lost faith in Bale last season, with the pair's relationship growing increasingly strained before Zidane announced his departure.
"I do not want to discuss the individual season of Gareth Bale, but in these 11 remaining games I will count on him as I do with everyone, and like the others he is ready to play".
It is clear Zidane is giving those who have been out of the team a chance to prove themselves and bring back the good times. The man who scored winning goals in the 2014 Copa del Rey final, 2014 Champions League final and a brace in last season's Champions League final, has been subjected to some of the most vitriolic abuse to come from Madridistas in recent years.
Victory for Zidane's side this afternoon will see them move to within in two points of second-place Atletico Madrid. "They showed that today, those who had played less - Keylor, Marcelo, Isco, Marco [Asensio] - all of them".
Zidane has also made a big call in goal, with Courtois dropping to the bench after a 4-1 comeback win at Real Valladolid last week and Costa Rica global Keylor Navas recalled.
The performances of Bale, Isco and Marcelo in particular have left him with plenty to ponder, and Zidane can only hope that vigour will continue after the worldwide break.
Johnny Manziel set to join AAF, report says
The 2012 Heisman Trophy victor at Texas A&M had his contract with the CFL terminated this offseason. Manziel was released by the Montreal Alouettes of the Canadian Football League earlier this month.