With both Juve and Barca in the hat for Friday's quarterfinal draw, the pair of generational greats could soon cross paths - although Messi said the challenge posed by any of the remaining teams was a tough one.
Barca put five goals past Lyon but it was not all smooth sailing for the LaLiga champions, who led 2-0 after 31 minutes thanks to Messi and Philippe Coutinho, only for Lucas Tousart to pull a goal back when the game was approaching the hour-mark.
Whilst the Ligue 1 side may have complaints about the penalty awarded for a foul on Luis Suarez, which Lionel Messi converted so well, they can hardly suggest that Barcelona weren't by far the superior team.
I thought Atletico would be stronger.
"In the second half, we had a better time".
Lyon's Lopes had to be taken off injured later in the first half, leaving the field in tears after taking a blow to the face, with Mathieu Gorgelin replacing him and making his Champions League debut.
The Catalan giants prevailed following the goalless first-leg draw in France in their round-of-16 tie.
He continued to torment the visitors, gifting defender Pique a sliding tap-in with a handsome pass and then setting up substitute Dembele.
Lyon goalscorer Tousart had little complaint about the final result and said his side were powerless to deal with Messi.
"There was a bit of suffering after they made it 2-1, as we'd made it tough for ourselves at a set piece".
"We had planned to play with a high block but the qualities of Barcelona did not allow us".
"Unfortunately, Barca scored their third goal at that moment. He has instinctive talent". "Sometimes he is just unstoppable".
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