Blood pressure medicine recalled after potential carcinogen is found in it

NMBA (N-Nitroso N-Methyl 4-amino butyric acid) is different than NDEA (N-nitrosodiethylamine) or NDMA, which have been the cause of previous Losartan, Valsartan and Irbesartan recalls.

USA health regulators said on Friday a third cancer-causing toxin was found in some blood pressure pills recalled by India's Hetero Labs Ltd a day earlier, adding to a global recall of commonly used drugs to treat hypertension.

The product subject to the recall is listed below.

Camber and Macleods are among the half dozen pharmaceutical firms that have recalled hypertension drugs found to contain possible carcinogens since early December. The full list can be seen here on the company's recall announcement on Thursday afternoon.

Almost 90 lots of Losartan potassium tablets made by Hetero Labs in India and distributed by Camber Pharmaceuticals were recalled Thursday due the discovery of trace amounts of N-Nitroso N-Methyl 4-amino butyric acid (NMBA), a probable carcinogen.


"That said, any presence of such impurities in drug products is not acceptable", FDA Commissioner Scott Gottlieb said in the statement. The company said it hadn't received any reports of patients being harmed related to the recall.

The affected Losartan tablets have expiration dates that run from September 2019 through June 2020.

And then there's Macleods Pharmaceuticals Limited, which announced on February 22, 2019, that it was initiating a recall on just one of its lots of Losartan tablets after traces of NDEA were detected by officials. Distributed nationwide online and by pharmacies and retailers including Walmart and Sam's Club, the drug was found to contain trace amounts of a potential human carcinogen, the New Jersey drug company said in a news release.

"Because of the potential for discovering other nitrosamine impurities, we are conducting an extensive organic chemistry analysis to develop novel testing methods to detect additional nitrosamine impurities, including NMBA".

You can also find more information about the recall at this link.

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