According to Palestinian figures, 640,000 Jewish settlers now live on 196 settlements (built with the Israeli government's permission) and more than 200 settler "outposts" (built without its permission) across the occupied West Bank and East Jerusalem.
Hebron and its environs are a frequent flashpoint, with the southern West Bank city divided between Israeli and Palestinian control and the two populations often coming into contact with each other.
"Apartheid Road", which was built more than 10 years ago, remained closed amid a dispute between the Israel Defense Forces and the country's police in connection with a new checkpoint.
Palestinian officials and activists on the other hand have condemned the road as an example of Israeli apartheid and racism against Palestinians.
"The opening of this road comes within the framework of Israel's ongoing efforts to undermine any chance of reaching a political solution", the ministry said in a Thursday statement.
Palestinian cartographer Khalil al-Tafakji warned Palestinian media outlets that opening the new road serves as a "prelude to displacing Palestinians from the area and starting settlement construction in the so-called E1 corridor".
A two-lane road built on a stolen land opens in occupied Jerusalem.
In the West Bank, Haaretz reports, more roads are exclusively reserved to Palestinians or Israelis.
Ahmed Mohammed al-Qaysi, a Palestinian driver for the Al-Zaim local council, does not have permission from Israel to cross the separation barrier and enter Jerusalem, like many Palestinians in the West Bank.
Jerusalem al-Quds is already separated from the West Bank by the so-called Israeli "apartheid wall".
The International Court of Justice said in 2004 that the apartheid wall violated international law and urged Israel to remove it.
Nissan top executive Munoz resigns amid broadened Ghosn probe
Ghosn's lawyer said earlier this week that his client would likely be held until the trial which could begin in about six months. It said it took the charges filed against the firm "extremely seriously" and was continuing its investigation into the case.