In terms of the visitors, the big news is that manager Claude Puel has handed a start to Harry Maguire, despite hinting earlier this week that the Man United target would only be fit enough for a place on the bench.
The Daily Mail says he kept his cool in front of the media ahead of Friday's Premier League opener against Leicester, but privately he was said to be angry and frustrated.
Last season may have been United's highest finish since Sir Alex Ferguson retired but the 19-point gap to runaway Premier League champions Manchester City underlined the improvements required.
"I will focus on the players that are available, so I am not even thinking about that list of injured players I gave you, (Nemanja) Matic, (Antonio) Valencia and so on".
"If they feel they can help us, 20 minutes, 10 minutes, half an hour".
Another player who has come through an uncertain summer with United is Anthony Martial, who was left out of his France's World Cup squad, prompting comments from his agent that he wished to leave Old Trafford to safeguard his global future.
The two-time Champions League victor added: "At this point I'd just say we need to win".
While the United hierarchy is known to be reluctant to sell the young striker, Mourinho has endured a trying time in his relationship with Martial after he left United's American pre-season tour to attend the birth of his child and did not return - missing nine days of training.
Ed Woodward has also been thrust into the limelight with Mourinho moaning at the lack of signings this transfer window.
Jose Mourinho's men have won two of their last three fixtures against Leicester to nil, including this exact fixture nearly 12 months ago when United eased home 2-0.
"I think what Jose Mourinho saw and what all of us saw in the summer was Paul Pogba smashing the middle of the France changing room, calling on the rest of the players, demanding more from them". "It is a lie, repeated 1,000 times".
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