With the draw opening up in her favour, Williams is widely expected to make history with a first Grand Slam title since the birth of her daughter Olympia in September previous year. Speaking about how his game perfectly suits the court condition at the All England Club, Federer said: 'Maybe it's that it helps my slice.
The 36-year-old Federer has qualified for the last-eight without dropping a set and now has won 32 straight sets at All England Club now.
Anderson has reached the last 16 for the fourth time and goes on to face France's Gael Monfils.
Mannarino won only one point on his own serve as Federer hit 11 winners to just one unforced error. Of the five points he lost, three were in the final game, when he faced his first break point of the tournament - and answered it with an ace.
The last of the women's top-10 seeds has been knocked out at Wimbledon.
The only significant test Williams should face in the bottom part of the bracket would come in the semifinals against Karolina Pliskova, Kiki Bertens or Julia Gorges. She beat the ninth-seeded Williams in the third round after coming from a break down in the third set. His confidence appeared fully intact, though, as he saved the first with a forehand onto the line, the second with a 107mph second serve and the third with an ace.
A single break of serve was all Nadal required in the opening set and he broke twice in the second.
Williams is 6-2 in her career against Kerber, but the match might be better than expected given the tight major finals played between the two in 2016. He could not quite make it to a tie-break, though, with Federer breaking for 6-5 and then serving out the set.
Hsieh returned the ball over the net and into the court as Cibulkova immediately challenged.
"They have been a positive four matches, I haven't played on grass for a year and I'm hoping to keep enjoying it".
After seven minutes, the decision was finally changed and the point replayed. Other early starters included No. 12 Jelena Ostapenko of Latvia facing Donna Vekic of Croatia and Camila Giorgi of Italy playing Russia's Ekaterina Makarova.
Nine of the top 16 seeds in the men's draw were eliminated in the first three rounds, and the carnage is even worse in the women's draw, as one of the top 10 seeds remains in contention entering the second week.
The world No 1 proved a quality act against Czech big-hitter Vesely as he swept to a 6-3 6-3 6-4 victory on Monday. Here he was playing around with Mannarino but the drop in pace allowed the 22nd seed to get a foothold in the match.
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But if some critics of France have been silenced by superb performances, it had been a different story in Belgium until recently. Their comeback win over Japan in the Round of 16 was stirring before narrowly beating Brazil in the quarter-finals .
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For all the talk about champion-vs-champion bouts over the years in the UFC, their actual history is just two chapters long. White couldn't when the fight against Cormier would take place but did confirm it would be happening.