"Right now, we are only anxious but we don't know how serious the injury really is". England have lost once in 21 games to Switzerland; their record against Sweden is more mixed but they haven't lost to them since a Euro 2000 qualifier back in 1998, which proved to be Glenn Hoddle's last game in charge.
But Russia soon got the equaliser in the 41st minute as Artem Dzyuba smashed home a penalty after his header was blocked by Gerard Pique's arm in the box.
Perennial underachievers on the worldwide stage, Spain rid themselves of that tag during a glorious cycle between 2008 and 2012 when they won back-to-back European Championships and a first World Cup. Iniesta also scored the first spot-kick of the shootout.
The decision to dispense with long-time coach Julen Lopetegui days before the World Cup after he failed to tell the federation about his move to Real Madrid after the tournament was inevitably brought up.
Russian Federation and Spain finished extra time with the score at 1-1.
Julen Lopetegui's dismissal on the eve of the tournament undoubtedly unsettled Spain, but Iniesta insisted the players have no excuse for not overcoming the hosts.
And Pique handled at the other end to concede a penalty before the break.
Igor Akinfeev. Any day you save two penalties in a shootout is a good day.
And the last game of the round of 16 features a Swedish side that won a tough group versus a Swiss team with issues in the back but enough talent up front to score against anyone.
"We are having a fantastic World Cup".
The rule is aimed at reducing injuries and allowing higher-quality play in extra time, when players are most exhausted.
Spain made its extra substitution about seven minutes later when Rodrigo Moreno replaced Marco Asensio. Still, World Cup history was on Russia's side after its well-organized team survived two hours of barely having the ball.
This will be the sixth World Cup match for the 43-year-old former maths teacher from Beachwood, New Jersey, and the third at this tournament. He refereed Portugal's 1-0 win over Morocco and Germany's 2-0 loss to South Korea, which eliminated the defending champions.
However after a couple of mistakes in the group stage, calls were made to see him dropped for Sunday's Round of 16 clash with hosts Russian Federation.
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