The 57-year-old actor, who is now filming a TV series on the Italian island, was understood to be driving to set when the incident occurred.
Italian paper La Nuova reported that he was rushed to the emergency room at John Paul II Hospital, but he is not believed to be seriously hurt.
A picture from La Nuova shows a smashed windscreen, which suggests George hit it during the crash, but despite this, his condition is not thought to be serious.
A fire extinguisher can be seen on the road but no people are visible.
HuffPost UK has contacted George's representatives for comment.
The American is on location in Sardinia to film a new mini-series "Catch 22".
George Clooney was reportedly involved in a vehicle accident on Monday. More information is to follow.
The stunning abode features two swimming pools, a tennis court and an incredibly colourful landscape.
Clooney has a home with his wife, human rights lawyer Amal, on the Italian mainland, on Lake Como.
"Catch 22" is an adaptation of Joseph Heller's classic novel and George is directing and starring in the series.
10 July 2018
10 July 2018
10 July 2018
10 July 2018
