Babies die after mums given Viagra in Dutch trial

Viagra trial baby deaths Dutch research project called off as 11 infants die

Half of the 183 mothers in the trial had been treated with sildenafil while the other half were treated with a placebo.

Researchers said their principle goal now is to find out what happened.

The trial, which began in January 2015 in 10 Dutch hospitals, was meant to treat women whose babies had life-threatening growth issues.

The hope was that the drug "can open up some blood vessels in the placenta and then can help the growth of the fetus", Pammi said.

Of the group, 9 babies that died soon after birth were from mothers in the placenta group and did not show any signs of lung problems. 17 of their children were born with a lung condition, . It said researchers expected all such usage of the drug to be stopped and that further research should examine the effects and safety of the substance when used in pregnancy. However, they also did not document any benefits.

He said: "The likelihood of developing a lung condition was much higher (among Viagra takers), as was the chances of death shortly after birth".

The clinical trial was led by the Amsterdam University Medical Centre.

In total, 93 women were given sildenafil and 90 were given a dummy drug or placebo.

More than a dozen things can cause intrauterine growth restriction, including maternal diseases like diabetes or high blood pressure, chromosomal abnormalities in the baby or several types of infection. In this group, three infants were born with lung involvement, none of them died.

The pregnant women who had agreed to take part in the trial all had unborn babies whose growth had been severely limited in the womb.

The statement from the medical center said sildenafil is sometimes used to treat women whose babies seem to not be growing well and noted that the practice will probably be discontinued.

AMSTERDAM-When gynecologist Wessel Ganzevoort received a request for an urgent meeting from the independent committee watching over his clinical trial last week, he thought it might be good news.

Now that it's no longer under patent, the drug is being explored by research companies as a wonder drug for a range of other conditions. A trial in Ireland has yet to start enrollment; researchers in that study did not respond to emails today, but Mol expects it will be canceled.

The company also issued a statement Wednesday noting that it did not fund or provide medication for the trial. A study by a team in the United Kingdom, published online in The Lancet Child & Adolescent Health in December 2017, found sildenafil didn't improve the duration of pregnancy, birth weight, or fetal and neonatal survival. The doctors decided that the child would be better to stay and develop inside the mother.

The center's researchers will analyze the now available data.

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