The pair sent down a combined 92 aces in the marathon contest on Court 15, with Karlovic accounting for 61 of them. The 30-year-old Makarova took down Wozniacki 6-4, 1-6, 7-5 to bring the Danish star's tournament to a surprisingly quick conclusion.
Russian world No 35 Makarova secured victory on her sixth match point after allowing Wozniacki to claw her way back from 5-1 down in the decider.
"Every time when I see an article or a video, especially which I enjoy a lot, I see something about the queue, I hear what they say, how excited they are about Wimbledon", he said.
"It was better than the first round".
The American has improved immensely at Grand Slam level, not only did he make the Wimbledon semi-finals but he also got to the quarter-finals at the US Open and that has largely been down to the improvements he has made to his big weaknesses.
John Isner saved two match points in the fifth set to overcome Belgian Ruben Bemelmans 6-1 6-4 6-7 (6) 6-7 (3) 7-5 in three hours 46 minutes to reach the third round.
It was another dominant display by the eight-time champion, who lost just nine of 61 points on his serve in total and broke Lacko five times, including with a forehand victor to close out the match. "I know for sure I have to play good tennis and play better than the last two matches here", 11th seed Kerber said after beating American Claire Liu 3-6 6-2 6-4. "Lacko can play well on the grass, he's won his fair share of matches".
Mladenovic won back-to-back matches at a major tournament for the first time since a year ago at Wimbledon, when she was in the midst of a career-best stretch that ultimately saw her crack the Top 10 for the first time last fall.
"Yeah, I'm very happy on both ends, absolutely", Federer said.
Seven-time champion Serena Williams faced little resistance in her progress to the third round as she overpowered Bulgarian qualifier Viktoriya Tomova 6-1, 6-4. "Sometimes your serve matches up better against certain players".
"Where I am in the village I can hear the Rose & Crown".
"Actually, I watched the shootout", he said. "Now I'm cheering for England".
The Slovakian is no mug, having been a beaten finalist at Eastbourne last week, but he could not cope with Federer's mastery as the Swiss racked up his 93rd Wimbledon win.
He also hammered down 16 aces on his way to winning 93% of his first-service points.
Italian Fabbiano saved three set points against three-times grand-slam victor Wawrinka in the second set to advance to the third round of a major for just the second time in his career.
Lucas Pouille became the latest seeded player to exit the men's draw after a 6-4 6-2 6-7 (8-10) 3-6 6-2 defeat to Austrian qualifier Dennis Novak. She promptly reeled off 12 of the next 13 games to wrap up a 4-6, 6-0, 6-1 victory.
Eight statistics that matter ahead of World Cup quarterfinals
Their team isn't blessed with world-class players, but they seem to be taking a leaf out of underdogs that have gone before them. Andersson's squad regrouped, and impressively defeated Mexico 3-0 in their final group match to progress to the knockout stage.