Polycystic ovary syndrome cause FINALLY discovered - and scientists might have the cure

Polycystic ovary syndrome

"It's by far the most common hormonal condition affecting women of reproductive age but it hasn't received a lot of attention", says Robert Norman at the University of Adelaide in Australia.

Researchers surmise that this could be why it has been so hard to find the specific cause of PCOS, as it was being passed from mother to daughter via hormones while still inside the womb.

Scientists at the French National Institute of Health and Medical Research measured levels of the hormone in a cohort of pregnant women with and without PCOS.

To test this, researchers injected pregnant mice with high levels of AMH and followed the development of their offspring postnatally.

Polycystic ovary syndrome (PCOS) is a common condition that affects how a woman's ovaries work.

Beyond helping women to get pregnant, this is an incredible breakthrough for those frustrated with the side effects from the condition, because they may at long last have relief.

PCOS affects how a woman's ovaries FUNCTION - symptoms may include irregular periods as well as difficulty in getting pregnant. It is marked by a group of symptoms that affect the process of ovulation, but its main features are the presence of growths in the ovary, high levels of male hormones, and irregular or skipped menstrual periods. The condition is typically characterised by high levels of testosterone, ovarian cysts, irregular menstrual cycles, and problems regulating sugar, but the causes have always been a mystery. Dr. Paolo Giacobini, head scientist of this study, and his team hope to start human trials by the end of the year.

"It's a radical new way of thinking about polycystic ovary syndrome and opens up a whole range of opportunities for further investigation", says Norman. In fact, many women may be living with PCOS and not even know it.

'It's something we've been stuck on for a long time'. In this condition, the ovary or ovaries develop multiple fluid-filled sacs that contain immature eggs that do not mature for ovulation.

This happens, the researchers found, because the hormone overstimulates the part of the brain causes testosterone levels to rise.

The team were able to reverse this effect in the mice using cetrorelix, an IVF drug routinely used to control women's hormones.

To test this idea, they injected excess anti-Müllerian hormone into pregnant mice.

Levels of the hormone are known to decline as women get older. It is a leading cause of female infertility also boosts the risk of metabolic problems like type 2 diabetes.

PCOS sufferers should have a healthy diet, including at least five portions of fruit and vegetables a day, lean meat and fish, and dairy products, while avoiding anything too fatty or sugary.



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