Zimbabwe is due to hold elections in 2018 in the first big test of Mnangagwa's legitimacy after he rose to power in November a year ago following a de facto military coup which saw veteran leader Robert Mugabe reluctantly cede power.
"We do not have any entitlement to lead, but we have a duty to serve", the former trade unionist, who has been at the helm of the MDC-T since its formation 18 years ago, said.
"As I have said before, while politicians only think about the next election, true statesmen think about the next generation, for current leaders are only but caretakers for future generations".
"We must recognize the imperative that new hands, with the full blessing of the people, must take this struggle and this country forward".
In June previous year, Tsvangirai appointed Nelson Chamisa and Elias Mudzuri as his deputies to join Thokozani Khupe as vice-presidents.
The opposition leader appreciated President Mnangagwa for taking time to visit him at his home last week to check on his health progress saying that the visit gives a new hope for political tolerance in the country.
"Currently there is no need", Mnangagwa told reporters, referring to the possibility of forming a coalition with Tsvangirai's Movement for Democratic Change (MDC).
"At a personal level, I feel an air of satisfaction as I reflect on the great journey we have travelled together even as I seriously ponder about the future", Tsvangirai said.
"Indeed, my engagement with President Mnangagwa must herald a new page in our politics-a page in which the opposition is considered a partner and not an enemy of the state", he said.
In his New Year message issued Monday, Tsvangirai said all well-meaning Zimbabweans should build on the visit to herald a new politics of engagement where political differences were celebrated and people allowed to express divergent views.
"The new government has to break away from the past and genuinely chart a new trajectory to a dispensation of clean politics that truly puts the country and its people first". President Mnangagwa together with Vice President, General Dr Constantine Chiwenga (Retired) last Friday visited Mr Tsvangirai at his house.
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