Trastuzumab Does Not Benefit HER2-Low Breast Cancer Patients

Dutch cancer survival rates have risen sharply since the 1960s

Cutler is hopeful that neratinib, which was approved in the extended adjuvant setting in breast cancer in July, can provide clinical benefit to the rare liver cancer patient population and, in this video, he explains why.

MONALEESA-7 investigated efficacy and safety of Kisqali in combination with tamoxifen or non-steroidal aromatase inhibitor plus goserelin in premenopausal or perimenopausal women with hormone-receptor positive, human epidermal growth factor receptor-2 negative (HR+HER2-) advanced breast cancer.

Hershman's team wondered if the ancient practice of acupuncture might help.

Novartis is looking for an expanded combination therapy label for its Kisqali after a trial showed it halts progression of an aggressive kind of breast cancer in younger women for longer than standard drugs.

"This is yet another study that reveals the benefits of acupuncture in treating pain", Coomer said. The BPI is a self-administered 14-item questionnaire created to assess pain on a scale from zero to 10, where higher scores indicate more pain. The patients were monitored for another 12 weeks after stopping acupuncture treatments, and reported on their pain using various methods, including the BPI, throughout this 24-week period.

"If something so simple as acupuncture can improve upon these symptoms and the patients' quality of life, we will have more women becoming compliant in taking their medication, and one would expect improved outcomes", Cassell added. Of the patients in the study, 110 received true acupuncture, 59 were given fake acupuncture - needles placed at ineffective spots on the body - and another 57 were placed on a waiting list.

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The study had a median follow-up of 46.1 months, during which time 264 patients had a recurrence, diagnosis of a new breast cancer, diagnosis of a new cancer outside the breast, or died. "We need to identify strategies to control these side effects, the most common of which is debilitating joint pain and stiffness".

Breastcancer.org has more on aromatase inhibitors. "We have a huge problem in this country with pain medications, and it's imperative to find alternative ways of controlling pain and discomfort so that individuals with breast cancer can stay on their treatment".

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