It happened in a rural area of Oldenburg, Indiana, shortly after 9 p.m. Saturday.
Three people and a dog died in the crash.
Wheeles said the plane was traveling from Kansas City, Missouri, to Frederick, Maryland, and had taken off from an airport outside Columbus, Indiana.
The plane was on fire at the time police arrived.
The three people, who have not been identified, were found dead at the scene along with one dog.
The surviving dog, after being found at a nearby home, was taken to a veterinarian for treatment of its injuries.
Sergeant Stephen Wheeles with the Indiana State Police kept the public updated of the situation on Twitter.
(Batesville, Ind.) - Autopsies are scheduled Monday on the three victims of a Saturday night airplane crash near Batesville and Oldenburg.
Hours later, the plane was being tracked by Cincinnati Air Traffic Control when it disappeared from radar.
The Indiana State Police was initially assisted by numerous police and fire departments in Franklin County as well as the Franklin County Coroner's Office.
Investigators are still working to confirm the identity of the people on the aircraft before releasing names.
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