Tottenham manager Mauricio Pochettino must decide whether to shuffle his pack for the trip. Charlie Austin is expected to miss the game after being charged with violent conduct for an incident that took place during Saturday's 1-1 draw with Huddersfield while defender Virgil Van Dijk will also miss out.
The corresponding fixture last season was a keenly contested affair, although first half goals from Dele Alli and Christian Eriksen helped Tottenham win a close game 2-1.
Saints have won just three of their 18 Premier League visits to Tottenham, most recently in May 2016 when Steven Davis scored both of Southampton's goals.
"Obviously our goals came late, but we pressed higher and tried to show what we are [capable of]".
Spurs aim to keep their top four hopes on track with a win as Harry Kane needs one more goal to set a new record for the most PL goals scored in a calendar year.
Harry Kane set to start for Spurs as he chases new record
In what will be a huge blow for the Saints, they are likely to be without key players. The England striker has scored 39 goals in 2017, beating Alan Shearer's record of 36 goals in 1995.
Tottenham striker Harry Kane scored a hat-trick at Wembley to help see off the Saints, taking the England worldwide to 39 Premier League goals in 2017.
Southampton have lost five of their last six away games at Tottenham, with the only win coming in May, 2016. They have won just one of those games, a 4-1 victory against Carlisle in the 2010 Football League Trophy final.
Tottenham would be aiming to move back into the top-four, albeit for a few hours, when they host Southampton at Wembley Stadium on Boxing Day.
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