Eminem's new single 'Walk On Water' featuring Beyonce is getting all kinds of reactions from the audience. Beyoncé, which the rapper performed as he opened the show.
Eminem was also named best hip-hop artist, and proclaimed surprise.
Notable performances included local London grime star Stormzy, who took to the stage poking out of the sunroof of a police vehicle, and Travis Scott, who entered standing atop what looked like a floating hawk.
Taylor Swift sees two hits bounce back into the Top 40 following the release of her new album Reputation: ... We love you. God bless you.
The best video, claimed by United States rapper Kendrick Lamar, was one of the few awards to be chosen by the MTV team.
Luckily Stormzy managed to escape the toilet in time to perform his single "Big For Your Boots".
Rita Ora shocked everyone withh her astonishing appearance dressed wit a dressing gown and a towel at MTV Music Awards 2017.
Kendrick Lamar won best video for "Humble", a lavish clip laced with religious and art-history imagery.
Cuban-American singer Camila Cabello was honoured with the best pop prize, while Coldplay snatched the best rock award. "Congratulations to all the winners and thank you to the incredible crowd!"
British singer-songwriter Dua Lipa was named best new artist.
Apart from the occasional hint of marijuana smoke wafting across the arena, there were few of the unscripted-feeling moments that made past shows stick in the memory.
U2, who played an MTV-sponsored concert in London's Trafalgar Square on Saturday, received the Global Icon award from Leto, who said "U2 changed my life". Their songs, our prayers, their concerts, a church. "They challenge us, they inspire us".
Mendes, 19, who launched his career by posting song covers to the internet before getting signed to a record label, also scooped the "biggest fans" award. Next year's ceremony will be held in Bilbao, Spain.