Hughton admits Duffy has yet to train this week, but isn't ruling him out of tomorrow's trip to the London Stadium.
Brighton are 14th on eight points with two wins, two draws and four losses, while West Ham are below them only on goal difference.
The Spanish goalkeeper has lost his number-one spot to Joe Hart and wants to go to the World Cup this summer. "It's a game away from home, in a big stadium, and irrespective of league positions, we're up against a very talented team", he told reporters on Thursday.
"We're a team that is having to get used to this division and the quality of it".
The former Manchester United forward has hit the ground running since returning to England from Germany's Bayer Leverkusen and will look to add to his three league goals for the club.
West Ham don't tend to slip up against visiting promoted sides, with their 2-0 victory over Huddersfield earlier this season their sixth in a row without defeat.
"I have played regularly for this Club for over a decade now, but we now have a bigger and stronger squad than ever and that means the manager will take decisions to pick certain players for certain matches".
"But they've got a lot of quality there and I always feel that when West Ham have a hard time, they will always come through it".
There was concern when Duffy, now a key member of the Irish defence, was substituted in the second half of his club's Premier League draw with Everton last week, the Derry man suffering from a groin injury.
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