While Jennings remains in the ECB's long-term plans, an inconsistent showing at the top of the order meant he never took full hold of the chance he was afforded to establish himself as Alastair Cook's opening partner.
The 25-year-old Jennings managed just 127 runs in eight innings during England's 3-1 series win over South Africa and was replaced by Mark Stoneman in the 13-man squad to face the Caribbeans from Thursday.
But the majority of eyes will be on Stoneman, a 30-year-old batsman who made his name with Durham before moving to Surrey in the winter.
National selector James Whitaker said: "Selectors would like to offer their congratulations to Mark Stoneman and Mason Crane who thoroughly deserve their opportunity in the squad".
Whitaker added: "Keaton Jennings will return to Durham and will look to recapture the form that earned him selection in the first place".
The leg-spinner has always been seen as the future of England's spin options but the resurgence of Moeen Ali, man of the series against South Africa, means his Test debut may be further away than first thought.
Sheer weight of runs appears to have seen Stoneman force his way in ahead of Haseeb Hameed, who made his Test debut in India previous year but has managed just one first-class score of more than fifty so far this season.
The Edgbaston day-night match is the first of three Tests between England and the West Indies, with the teams meeting again at Headingley before the series concludes at Lord's.
Since swapping Durham for Surrey earlier this year, Stoneman has amassed 828 runs at an average of 59.14 in the championship and is well on course to pass 1,000 for the fifth year running.
"He hasn't had the best of series".
'Chris Woakes has proved his fitness and returns to the squad having missed most of the summer through injury.
Tom Westley, number 679, retains his place in the squad while Chris Woakes returns to the squad and could displace the unfortunate Toby Roland-Jones, who has impressed in his brief opportunity as an global seamer.
England squad: Joe Root (captain), Moeen Ali, James Anderson, Jonny Bairstow (wicketkeeper), Stuart Broad, Alastair Cook, Mason Crane, Dawid Malan, Toby Roland-Jones, Ben Stokes, Mark Stoneman, Tom Westley, Chris Woakes.
Protesters Storm Abuja, Ask Buhari to Return Home
On the second preturn, or resignation or certain explanations, I would say that they have over stepped their bounds. He said, "They (the protesters) are only exercising their rights in line with the constitution of this country".
IL misses school payments, sends grant money
Roughly $135 million will go to the financially struggling Chicago Public Schools , according to the comptroller's office. State aid checks were supposed to arrive this week, but that's been delayed because of the Gov.
Oxford Circus Tube station evacuated due to smoke
The British Transport Police confirmed there was a fire and said it is not now being treated as suspicious. Some people were running up the escalator but they had shut certain exits, although it was very orderly.